The 6875 Freezer/Mill is a large cryogenic mill that can grind up to 0.1 - 100 grams of samples. It is specifically designed to cryogenically grind tough and/or temperature sensitive samples. The mill cools samples to cryogenic temperatures, then pulverizes them by magnetically shuttling a steel impactor back and forth against two stationary end-plugs. Since the vial is closed, the integrity of its contents is maintained, hazardous or critical samples are easily controlled, cleanup is simplified and cross-sample contamination is eliminated. The new high resolution display is user-friendly and includes the following features:
Run history which is uploadable to a thumb drive via USB
Training videos and manuals that can be viewed on the screen.
A complete listing of accessories
Applications include: DNA/RNA extraction, THC extraction, protein extraction, forensic testing, materials testing, pharmaceutical analysis, drug testing, RoHS/WEEE and volatiles extraction.
Typical samples include: Animal tissue, plastic and polymers, yeast, pharmaceuticals, food products, electronic components, textiles, hair, teeth, bones, plant tissue such as cannabis, seeds, leaves and roots.
Liquid nitrogen required for operation. Equipped with liquid nitrogen level sensor, insulated case and lid safety interlock switch for operator protection.
Grinding Vial Sets offered in a variety of materials including polycarbonate, stainless steel, and Cr-free steel.
Grinds samples in the 0.1 - 100 gram range. Grinding chamber holds one large grinding vial, one mid-size vial, four standard grinding vials or four microvial sets.
Auto-Fill System available for automated filling with liquid nitrogen. Order model number 6875A Freezer/Mill.
Dimensions 20.5 in (52cm) x 21.5 in (55cm) x 18 in (46cm)
Voltage 115V/60Hz or 230V/50Hz
Net Weight (lbs) 44 lbs (24kg)
Power Cord 3-prong grounded plug, 115V 60Hz or 2-prong European plug, 230V / 50Hz
Timer/Controls Touch-screen programmable controls for grinding cycles, time, impact rate, pre-cooling and cooling times. Stores 20 grinding programs.
CE Approved Yes
Vials And Vial Sets
6751 (6751) SMALL GRINDING VIAL SET View Details
6751C20 (6751C20) SMALL POLYCARBONATE CENTER CYLINDER View Details
6751C4 (6751C4) SMALL POLYCARBONATE CENTER CYLINDER PACK OF 4 View Details
6751E (6751E) SMALL STAINLESS STEEL END PLUGS View Details
6751P (6751P) SMALL STAINLESS STEEL IMPACTOR View Details
6757 (6757) MICROVIAL SET View Details
6757C3 (6757C3) MICROVIAL CYLINDER View Details
6757P (6757P) MICROVIAL IMPACTOR View Details
6759 (6759) MICROVIAL HOLDER View Details
6761 (6761) SMALL POLY-VIAL SET View Details
6761P (6761P) SMALL POLYCARBONATE ENCAPSULATED IMPACTOR View Details
6771 (6771) SMALL CR-FREE GRINDING VIAL SET View Details
6771E (6771E) SMALL CR-FREE STEEL END PLUGS View Details
6771P (6771P) SMALL CR-FREE STEEL IMPACTOR View Details
6781E 6781E REPLACEMENT END PLUGS FOR 6781S View Details
6781O 6781O O-RINGS FOR 6781S View Details
6801 (6801) LARGE GRINDING VIAL SET View Details
6801C20 (6801C20) LARGE POLYCARBONATE CENTER CYLINDER
PACK OF 20 View Details
6801C4 (6801C4) LARGE POLYCARBONATE CENTER CYLINDER - PACK OF 4 View Details
6801E (6801E) LARGE STAINLESS STEEL END PLUGS View Details
6801P (6801P) LARGE STAINLESS STEEL IMPACTOR View Details
6802 (6802) LARGE STAINLESS STEEL CENTER CYLINDER View Details
6803 (6803) LARGE STAINLESS STEEL VIAL SET View Details
6870S (6870S) GRINDING VIAL ACCESSORY PACKAGE View Details
6871 (6871) LARGE CR-FREE GRINDING VIAL SET View Details
6871E (6871E) LARGE CR-FREE STEEL END PLUGS View Details
6871P (6871P) LARGE CR-FREE STEEL IMPACTOR View Details
6881 (6881) MID-SIZE GRINDING VIAL SET View Details
6881C20 (6881C20) MID-SIZED POLYCARBONATE CENTER CYLINDER PACK OF 20 View Details
6881C4 (6881C4) MID-SIZE POLYCARBONATE CENTER CYLINDERS View Details
6881E (6881E) MID-SIZE STAINLESS STEEL END PLUGS View Details
6881P (6881P) MID-SIZE STAINLESS STEEL IMPACTOR View Details
6883 (6883) MID-SIZE CR-FREE GRINDING VIAL SET View Details
6883E (6883E) MID-SIZE CR-FREE STEEL END PLUGS View Details
6883P (6883P) MID-SIZE CR-FREE STEEL IMPACTOR View Details
6885 (6885) MID-SIZE POLY-VIAL SET View Details
6885E (6885E) MID-SIZE POLYCARBONATE END PLUGS View Details
6885P (6885P) MID-SIZE POLYCARBONATE ENCAPSULATED IMPACTOR View Details
Racks & Holders
6755 (6755) VIAL RACK FOR SMALL GRINDING VIALS View Details
6805 (6805) VIAL RACK FOR LARGE GRINDING VIALS View Details
6753C (6753C) SAMPLE EXTRACTION TOOL View Details
6754 (6754) SMALL EXTRACTOR/VIAL OPENER View Details
6756 (6756) EXTRACTOR FOR SMALL VIALS View Details
6758 (6758) EXTRACTOR FOR MICROVIALS View Details
6791 6791 - VIAL IMPACTOR EXTRACTOR FOR FREEZER/MILL VIALS View Details
6804 (6804) LARGE EXTRACTOR/VIAL OPENER View Details
6808 (6808) LARGE VIAL EXTRACTOR View Details
6807 (6807) MULTI-VIAL HOLDER FOR SMALL & MICRO VIALS View Details
6808M (6808M) MID-SIZE VIAL ADAPTER KIT View Details
6870M-1 (6870M-1) MID-SIZE VIAL ADAPTER PACKAGE View Details
6887 (6887) MID-SIZED VIAL ADAPTER View Details
6888 (6888) MID-SIZE VIAL ADAPTER-CLOSED END View Details
Accessory Packages & Kits
6870L (6870L) LARGE GRINDING VIAL ACCESSORY PACKAGE View Details
Liquid Nitrogen Handling
54006 (54006) DIFFUSER View Details
6900L (6900L) CRYOGENIC GLOVES, SIZE LARGE View Details
6900M (6900M) CRYOGENIC GLOVES, SIZE MEDIUM View Details
6900S (6900S) CRYOGENIC GLOVES, SIZE SMALL View Details
6900XL (6900XL) CRYOGENIC GLOVES, SIZE EXTRA LARGE View Details
6906 (6906) SHORT CRYOGENIC TRANSFER HOSE, 4 FT (1.2 M) View Details
6907 (6907) LONG CRYOGENIC TRANSFER HOSE, 6 FT (1.8M) View Details
Tissue Homogenization and Cell Lysis
What are the applications for the Geno/Grinder??
The SPEX SamplePrep 2010 Geno/Grinder? was originally designed as a titer plate shaker for extracting DNA from seeds and plant tissue. This involved shaking two sealed, 96-well titer plates with plant tissue, buffer, and a steel grinding ball in each well. Over the years, the versatility of the Geno/Grinder design has enabled it to accommodate a wider variety of sample containers and sample types. Not only can it be used for high-throughput tissue homogenization, DNA/RNA and protein extraction, it can also be used for lysing bacteria and yeast. Most recently it has been used to increase sample throughput for pesticide residue analysis using the QuEChERS method. A wide range of Application Notes are available which discuss the various Geno/Grinder? applications in more detail.
What are the advantages of the Geno/Grinder? over other tissue homogenizers?
Unlike other tissue homogenizers which clamp titer-plates on their side and move in a "figure-eight motion", the 2010 Geno/Grinder? uses a vertical shaking motion - a much more efficient grinding process. This ensures that the grinding media impacts the sample each and every time and ultimately results in higher yields. Another benefit of the vertical grinding action is that titer-plates and vials are kept in their upright position, eliminating potential well-to-well contamination. The Geno/Grinder is also able to accommodate a larger quantity and variety of sample formats including micro-centrifuge and PCR tubes, titer-plates, vial sets, and conical bottom centrifuge tubes. The list of Geno/Grinder accessories has been greatly expanded making it possible to grind a much wider range of samples. Cryo-Blocks? and related Kryo-Tech? accessories preserve temperature sensitive samples and can be used for extracting RNA and proteins from both plant and animal tissue.
What are the benefits of grinding at low temperatures?
Most samples become embrittled at low temperatures, making them easier to grind. When working with nucleic acids, grinding at low temperatures can also result in higher yields.
What type of samples can I process in the Geno/Grinder??
The 2010 Geno/Grinder? can be used for a variety of samples including plant tissues like soybeans, sugar beet leaves, fungi, and seeds. It also grinds animal tissues like liver and fat and can lyse yeast and bacterial cells.
Grinding and Pulverizing
How to I choose a laboratory mill?
If your samples can be pulverized by impact at room temperature, you have a choice of several proven SPEX SamplePrep laboratory mills. The 8530 Enclosed Shatterbox? and 8500 Shatterbox? are ring-and-puck mills that are ideal for rapid grinding of samples up to approximately 100 grams, in 5 minutes or less. The 8000M Mixer/Mill? and 8000D Dual Mixer/Mill? are high-energy ball mills that not only pulverize samples in the 10 gram range but are suitable for blending powders and making emulsions up to approximately 50 mL. The 5100 Mixer/Mill? is a smaller high-energy ball mill, with about 10% the sample capacity of the 8000-series Mixer/Mills. All these mills have multiple-sample capacity with smaller samples, and a wide choice of grinding container sizes and materials, for maximum on-the-job flexibility over a wide rangeof applications. Soft, brittle materials and flexible samples that can be ground by shearing as well as impact may be suitable for the 5200 Micro Hammer-Cutter Mill, which uses revolving hammers in a chamber with a serrated lining. Product particle size is controlled by perforated screens in the bottom of the grinding chamber. This is the only "flow-through" mill sold by SPEX SamplePrep, and has proven useful for a comparatively narrow range of samples. The 6770 Freezer/Mill? and 6870 Freezer/Mill? are unique cryogenic mills that can grind almost any "ungrindable" sample, including all plant and animal tissue, most polymers, and countless other samples that are resistant to room-temperature milling. Freezer/Mills require liquid nitrogen for chilling the sample, and maintaining cryogenic temperatures in the vial during grinding. Forty years after its introduction the Freezer/Mill remains the most widely used and most effective cryogenic mill in the world. Finally, the 2010 Geno/Grinder? is a high-throughput tissue homogenizer with an adjustable clamp that accommodates a variety of formats ranging from deep-well titer plates to centrifuge tubes. It is specifically designed for rapid cell disruption, lysis, and tissue homogenization while preserving temperature sensitive samples. To discuss any SPEX SamplePrep laboratory mills and their suitability for your applications, feel free to contact our product specialists. We also offer test-grinding of your samples in our applications lab, or we can loan you a mill for short-term trials in your own lab. The more you know about SPEX SamplePrep laboratory mills, the more
How have the Freezer/Mills? been used in the field of medical research?
Medical schools and research hospitals have long used Freezer/ Mill technology in a variety of unconventional projects. One is the pulverizing of fresh, sterilized bone to use as a cement in joint-replacement surgery. The tiny bone fragments act as growth nuclei to stimulate the formation of bone around prosthetic implants. Another is the homogenizing of heart tissue to smear on slides as a culture medium. Freezer/Mills have even been used to grind implant materials to a fine powder which can be injected into live subjects for allergy and toxicity testing. At dental schools cryogenic grinding is used to pulverize fresh teeth without degrading them through heating. The overall possibilities in the medical field seem endless. A wide range of Application Notes which discuss the various Freezer/Mill? applications in more detail are available.
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